One if four Veterans is engaged in using recreationally legal drugs including tobacco cannabis and alcohol and one in 6 Veterans engage in two or more substances. These substances are both used to self-medicate and cause a variety of comorbid conditions. Tobacco is linked to both cardiovascular disease, lung disease and cancers. Vaping has been linked to lung injury, alcohol to cardiovascular disease, stroke, depression, cancer and depression. The VA has made remarkable strides in creating programs to address tobacco use and alcohol use. The VA hosts robust programs in tobacco cessation and alcohol use treatment. Yet, in the past decade there has been little decrease in the proportion of Veterans smoking tobacco, risky alcohol use has increased post pandemic and cannabis use is increasing among Veterans and the general population. In addition, new nicotine products and cannabis products are marketed to the public and Veterans with unknown risks. Research demonstrates that there is remarkable co-use of these 3 substances driven by their widespread availability. We propose to (1) establish a center focused on targeting these lifestyle choices among Veterans by building on currently available programs and testing innovative cutting edge programs that identify Veterans who may be ready to change (at hospital discharge, at the point of cancer diagnosis, during pregnancy, preoperatively for elective surgery) (2) mentor and develop fellows and faculty to develop and test interventions to stop the use of tobacco, reduce heavy and risky alcohol use and reduce heavy or problematic cannabis use. (3) work with local, VISN level and national operational partners to establish and disseminate successful programs.